Santino, played by Zaijian Jaranilla, is an orphan boy who became a ward of the local parish church shortly after he was born and was thus raised by priests. Longing for the love of his biological mother, he crosses paths with Jesus whom he affectionately nicknamed "Bro". Upon being granted healing powers, Santino sets out to aid those surrounding him in his home town, from folks with illness, to hardened criminals and disillusioned men who bitterly left their faith.